Two sample MR report
ELP5_Alveolar Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | -0.0442866 | 0.3968862 | 0.9154934 |
| Weighted median | 7 | -0.0854294 | 0.0222508 | 0.0001233 |
| Inverse variance weighted | 7 | -0.0852231 | 0.0181391 | 0.0000026 |
| Simple mode | 7 | -0.0861227 | 0.0308300 | 0.0314335 |
| Weighted mode | 7 | -0.0861227 | 0.0291525 | 0.0254735 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.1710724 | 5 | 0.9993942 |
| Inverse variance weighted | 0.1817334 | 6 | 0.9998832 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0273651 | 0.2650319 | 0.9217763 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.000102 | 0 | TRUE | 0.3400082 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
